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Article

BOK displays cell death‐independent tumor suppressor activity in non‐small‐cell lung carcinoma

26 Jul 2017

Abstract excerpt

As the genomic region containing the Bcl-2-related ovarian killer (BOK) locus is frequently deleted in certain human cancers, BOK is hypothesized to have a tumor suppressor function. In the present study, we analyzed primary non-small-cell lung carcinoma (NSCLC) tumors and matched lung tissues from 102 surgically treated patients. We show that BOK protein levels are significantly downregulated in NSCLC tumors as...

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PMID: 28744854
DOI: 10.1002/ijc.30906

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