Article
Genome-wide identification of lineage and locus specific variation associated with pneumococcal carriage duration.
eLife - 25 Jul 2017
Lees John A, Croucher Nicholas J, Goldblatt David, Nosten François, Parkhill Julian, Turner Claudia, Turner Paul, Bentley Stephen D
Abstract excerpt
Streptococcus pneumoniae is a leading cause of invasive disease in infants, especially in low-income settings. Asymptomatic carriage in the nasopharynx is a prerequisite for disease, but variability in its duration is currently only understood at the serotype level. Here we developed a model to calculate the duration of carriage episodes from longitudinal swab data, and combined these results with whole genome...
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