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Article

The resident pathobiont Staphylococcus xylosus in Nfkbiz-deficient skin accelerates spontaneous skin inflammation

18 Jul 2017

Abstract excerpt

Abstract IκBζ, which is encoded by the Nfkbiz gene, is a member of the nuclear IκB family of proteins that act as transcriptional regulators via association with NF-κB. Nfkbiz-deficient (Nfkbiz−/−) mice develop spontaneous dermatitis; however, the underlying mechanism has yet to be elucidated. In our study, we found higher skin pathology scores and more serum IgE antibodies and trans-epidermal water loss in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28740238
DOI: 10.1038/s41598-017-05740-z

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