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Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants.

International journal of obesity (2005) - 1 Dec 2017

Celis-Morales C A, Lyall D M, Gray S R, Steell L, Anderson J, Iliodromiti S, Welsh P, Guo Y, Petermann F, Mackay D F, Bailey M E S, Pell J P, Gill J M R, Sattar N

Abstract excerpt

BACKGROUND: Obesity is a multifactorial condition influenced by both genetics and lifestyle. The aim of this study was to investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) and body mass index (BMI) or waist circumference (WC) was modified by macronutrient intake in a large general population study. METHODS: This study included cross-sectional data from...

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PMID: 28736445
DOI: 10.1038/ijo.2017.169

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