Article
Variation in endoglin pathway genes is associated with preeclampsia: a case-control candidate gene association study.
BMC pregnancy and childbirth - 1 Apr 2013
Bell Mandy J, Roberts James M, Founds Sandra A, Jeyabalan Arun, Terhorst Lauren, Conley Yvette P
Abstract excerpt
BACKGROUND: Preeclampsia is a hypertensive, multi-system pregnancy disorder whose pathophysiology remains unclear. Elevations in circulating soluble endoglin (sENG) and placental/blood ENG mRNA expression antedate the clinical onset of preeclampsia. This study investigated if endoglin (ENG) pathway genetic variation was also associated with the development of preeclampsia. METHODS: We used a case-control...
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