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Article

Germline and reproductive tract effects intensify in male mice with successive generations of estrogenic exposure

20 Jul 2017

Abstract excerpt

The hypothesis that developmental estrogenic exposure induces a constellation of male reproductive tract abnormalities is supported by experimental and human evidence. Experimental data also suggest that some induced effects persist in descendants of exposed males. These multi- and transgenerational effects are assumed to result from epigenetic changes to the germline, but few studies have directly analyzed germ...

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PMID: 28727826
DOI: 10.1371/journal.pgen.1006885

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