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Article

Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2017

Bannon Amber E, Kent Jason, Forquer Isaac, Town Ajia, Klug Lillian R, McCann Kelly, Beadling Carol, Harismendy Oliver, Sicklick Jason K, Corless Christopher, Shinde Ujwal, Heinrich Michael C

Abstract excerpt

Purpose: Patients who inherit a pathogenic loss-of-function genetic variant involving one of the four succinate dehydrogenase (SDH) subunit genes have up to an 86% chance of developing one or more cancers by the age of 50. If tumors are identified and removed early in these high-risk patients, they have a higher potential for cure. Unfortunately, many alterations identified in these genes are variants of unknown...

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Source

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Identifiers

PMID: 28724664
DOI: 10.1158/1078-0432.CCR-17-1397
PMCID: PMC6011831

Genes

SDHA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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