Article
Simple generation of hairless mice for in vivo imaging.
Experimental animals - 30 Oct 2017
Hoshino Yoshikazu, Mizuno Seiya, Kato Kanako, Mizuno-Iijima Saori, Tanimoto Yoko, Ishida Miyuki, Kajiwara Noriko, Sakasai Tomoki, Miwa Yoshihiro, Takahashi Satoru, Yagami Ken-Ichi, Sugiyama Fumihiro
Abstract excerpt
The in vivo imaging of mice makes it possible to analyze disease progress non-invasively through reporter gene expression. As the removal of hair improves the accuracy of in vivo imaging, gene-modified mice with a reporter gene are often crossed with Hos:HR-1 mutant mice homozygous for the spontaneous Hrhr mutation that exhibit a hair loss phenotype. However, it is time consuming to produce mice carrying both the...
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