Article
A comparative study of phenotypic and genotypic first- and second-line drug resistance testing of Mycobacterium tuberculosis.
Biologicals : journal of the International Association of Biological Standardization - 1 Sept 2017
Sakhaee Fatemeh, Ghazanfari Morteza, Ebrahimzadeh Nayereh, Vaziri Farzam, Jamnani Fatemeh Rahimi, Davari Mehdi, Gharibzadeh Safoora, Mandjin Fatemeh Hemati, Fateh Abolfazl, Siadat Seyed Davar
Abstract excerpt
This study aimed to evaluate the frequency of resistance to first- and second-line drugs using phenotypic and genotypic methods and its correlation with resistance-linked mutations in Mycobacterium tuberculosis (M. tb) isolated in Iran. Three different methods, including the indirect proportion method(PM), direct and indirect nitrate reductase assay(NRA), and direct sequencing were used to assess drug resistance....
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