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Article

Exposure to reversine affects the chondrocyte morphology and phenotype in vitro.

Journal of tissue engineering and regenerative medicine - 1 Mar 2018

Gasparini S, Villa F, Molfetta L, Repaci E, Castagnola P, Quarto R, Giannoni P

Abstract excerpt

Articular chondrocytes derived from osteoarthritic tissues (OA HAC) show a severely reduced chondrogenic commitment. This impairment undermines their use for tissue-engineered cartilage repair, which relies on cell proliferation and growth to meet therapeutic needs, but also on efficient cell plasticity to recover the chondrogenic phenotype. Reversine (Rev), a 2,6-disubstituted purine inhibitor of...

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PMID: 28714568
DOI: 10.1002/term.2515

Genes

SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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