Detecting human coronary inflammation by imaging perivascular fat.

doi:10.1126/scitranslmed.aal2658

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Article

Detecting human coronary inflammation by imaging perivascular fat.

Science translational medicine - 12 Jul 2017

Antonopoulos Alexios S, Sanna Fabio, Sabharwal Nikant, Thomas Sheena, Oikonomou Evangelos K, Herdman Laura, Margaritis Marios, Shirodaria Cheerag, Kampoli Anna-Maria, Akoumianakis Ioannis, Petrou Mario, Sayeed Rana, Krasopoulos George, Psarros Constantinos, Ciccone Patricia, Brophy Carl M, Digby Janet, Kelion Andrew, Uberoi Raman, Anthony Suzan, Alexopoulos Nikolaos, Tousoulis Dimitris, Achenbach Stephan, Neubauer Stefan, Channon Keith M, Antoniades Charalambos

Abstract excerpt

Early detection of vascular inflammation would allow deployment of targeted strategies for the prevention or treatment of multiple disease states. Because vascular inflammation is not detectable with commonly used imaging modalities, we hypothesized that phenotypic changes in perivascular adipose tissue (PVAT) induced by vascular inflammation could be quantified using a new computerized tomography (CT)...

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Identifiers

PMID: 28701474
DOI: 10.1126/scitranslmed.aal2658

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