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Article

Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder

1 Jun 2017

Abstract excerpt

Abstract: Autistic spectrum disorder (ASD) is a neurodevelopmental disorder and has a high prevalence in children. Recently, mitochondrial oxidative stress has been proposed to be associated with ASD. Besides, SIRT1/PGC-1α signaling plays an important role in combating oxidative stress. In this study, we sought to determine the role of SIRT1/PGC-1α signaling in the ASD lymphoblastoid cell lines (LCLs). In this...

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PMID: 28694700
DOI: 10.2147/ndt.s129081

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