Article
Sofosbuvir-velpatasvir: A single-tablet treatment for hepatitis C infection of all genotypes.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists - 15 Jul 2017
Miller Misty M
Abstract excerpt
PURPOSE: The pharmacology, pharmacokinetics, interaction potential, efficacy, and safety of the newest direct-acting antiviral (DAA) medication for the treatment of chronic hepatitis C are reviewed. SUMMARY: Nonstructural proteins 5A (NS5A) and 5B (NS5B) are key drivers of hepatitis C virus (HCV) replication. Velpatasvir, an inhibitor of NS5A, was coformulated with the NS5B inhibitor sofosbuvir to provide a...
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