Article
Genetic risk factors for myocardial infarction more clearly manifest for early age of first onset.
Molecular biology reports - 1 Aug 2017
Titov Boris V, Osmak German J, Matveeva Natalia A, Kukava Nino G, Shakhnovich Roman M, Favorov Alexander V, Ruda Mikhail Ya, Favorova Olga O
Abstract excerpt
Epidemiological genetics established that heritability in determining the risk of myocardial infarction (MI) is substantially greater when MI occurs early in life. However, the genetic architecture of early-onset and late-onset MI was not compared. We analyzed genotype frequencies of SNPs in/near 20 genes whose protein products are involved in the pathogenesis of atherosclerosis in two groups of Russian patients...
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