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Article

Characterization of kinesin switch I mutations that cause hereditary spastic paraplegia.

PloS one - 1 Jan 2017

Jennings Scott, Chenevert Madeline, Liu Liqiong, Mottamal Madhusoodanan, Wojcik Edward J, Huckaba Thomas M

Abstract excerpt

Kif5A is a neuronally-enriched isoform of the Kinesin-1 family of cellular transport motors. 23 separate mutations in the motor domain of Kif5A have been identified in patients with the complicated form of hereditary spastic paraplegia (HSP). We performed in vitro assays on dimeric recombinant Kif5A with HSP-causing mutations in the Switch I domain, which participates in the coordination and hydrolysis of ATP by...

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Identifiers

PMID: 28678816
DOI: 10.1371/journal.pone.0180353
PMCID: PMC5498027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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