Article
Randomized Trial Comparing Esomeprazole and Rabeprazole in First-line Eradication Therapy for Helicobacter pylori Infection based on the Serum Levels of Pepsinogens.
Internal medicine (Tokyo, Japan) - 1 Jan 2017
Shimoyama Tadashi, Chinda Daisuke, Sawada Yoshihiko, Komai Kazuo, Chiba Hironobu, Saito Yoshiharu, Sasaki Yoshio, Matsuzaka Masashi, Fukuda Shinsaku
Abstract excerpt
Objective CYP2C19 metabolic activity influences the efficacy of Helicobacter pylori eradication therapies comprising PPIs. Rabeprazole (RPZ) and esomeprazole (EPZ) are PPIs not extensively metabolized by CYP2C19. The aim of this study was to elucidate whether or not first-line triple therapies using RPZ or EPZ are equally effective in Japanese patients with different CYP2C19 genotypes. Methods Two-hundred...
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