Host-mediated impairment of parasite maturation during blood-stage Plasmodium infection

Abstract excerpt

Significance Adaptive immunity to Plasmodium falciparum takes years to develop in endemic regions, leaving young children vulnerable to high parasite burdens and severe malaria. Host innate immune responses clearly occur during infection and may control parasite numbers in nonimmune individuals, for example by accelerating parasite removal from circulation. However, evidence of whether and how this occurs in vivo...

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