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Article

CXCR2 +1208 CT genotype may predict earlier clinical stage at diagnosis in patients with prostate cancer.

Cytokine - 1 Sept 2017

Franz Juliana M, Portela Pâmela, Salim Patricia H, Berger Milton, Fernando Jobim Luiz, Roesler Rafael, Jobim Mariana, Schwartsmann Gilberto

Abstract excerpt

Interleukin-8 (IL-8) is an angiogenic CXC chemokine that plays an important role in both the development and progression of several human malignancies including prostate cancer (PC). A single nucleotide polymorphism (SNP) at -251 upstream of the transcriptional start site of the IL-8 gene has been shown to influence its production. The effects of IL-8 are mediated by two highly related chemokine receptors, CXCR1...

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Identifiers

PMID: 28668699
DOI: 10.1016/j.cyto.2017.06.001

Genes

CXCR2
CXCR1

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