Article
CXCL12 G801A polymorphism is a risk factor for sporadic prostate cancer susceptibility.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2007
Hirata Hiroshi, Hinoda Yuji, Kikuno Nobuyuki, Kawamoto Ken, Dahiya Angela V, Suehiro Yutaka, Tanaka Yuichiro, Dahiya Rajvir
Abstract excerpt
PURPOSE: The chemokine CXCL12 and its receptor CXCR4 have been found to be associated with cancer metastasis. A single nucleotide polymorphism of CXCL12 G801A has been described and is regarded as a target for cis-acting factor that has the ability to up-regulate CXCL12 expression. Currently, there are no reports investigating the role of CXCL12 G801A polymorphism in prostate cancer (PC). EXPERIMENTAL DESIGN: We...
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