Article
Genetic polymorphisms of vitamin D metabolism genes and serum level of vitamin D in colorectal cancer.
The International journal of biological markers - 31 Oct 2017
Marques Vidigal Verônica, Aguiar Junior Pedro Nazareth, Donizetti Silva Tiago, de Oliveira Juliana, Marques Pimenta Célia Aparecida, Vitor Felipe Aledson, Manoukian Forones Nora
Abstract excerpt
BACKGROUND: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels. The aim of this study was to investigate the relationship of the polymorphisms of VDR (ApaI and BsmI), CYP27B1 and CYP24A1 with serum vitamin D levels in both forms, 25(OH)D3 (circulating form) and 1,25(OH)2D3 (active form), in colorectal cancer (CRC)...
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