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Article

The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment.

Molecules (Basel, Switzerland) - 29 Jun 2017

Schopfer Lawrence M, Delacour Hervé, Masson Patrick, Leroy Jacqueline, Krejci Eric, Lockridge Oksana

Abstract excerpt

Humans with the C5 genetic variant of butyrylcholinesterase (BChE) have 30-200% higher plasma BChE activity, low body weight, and shorter duration of action of the muscle relaxant succinylcholine. The C5 variant has an extra, slow-moving band of BChE activity on native polyacrylamide gel electrophoresis. This band is about 60 kDa larger than wild-type BChE. Umbilical cord BChE in 100% of newborn babies has a...

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Source

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Identifiers

PMID: 28661448
DOI: 10.3390/molecules22071083
PMCID: PMC6152381

Genes

RAPH1
BCHE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment.PMID 28661448Read ↗

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