Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A microRNA signature of response to erlotinib is descriptive of TGFβ behaviour in NSCLC.

Scientific reports - 23 Jun 2017

Krentz Gober Madeline, Collard James P, Thompson Katherine, Black Esther P

Abstract excerpt

Our previous work identified a 13-gene miRNA signature predictive of response to the epidermal growth factor receptor (EGFR) inhibitor, erlotinib, in Non-Small Cell Lung Cancer cell lines. Bioinformatic analysis of the signature showed a functional convergence on TGFβ canonical signalling. We hypothesized that TGFβ signalling controls expression of the miRNA genes comprising an erlotinib response signature in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Enzyme Activation
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Erlotinib Hydrochloride

Share to Extracellular Signal-Regulated MAP Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Smad Proteins

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 28646226
DOI: 10.1038/s41598-017-04097-7
PMCID: PMC5482799

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A microRNA signature of response to erlotinib is descriptive of TGFβ behaviour in NSCLC.PMID 28646226Read ↗

A Transcriptional Program for Detecting TGFβ-Induced EMT in Cancer.Semantic proximity Read ↗

The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors.Semantic proximity Read ↗

TGF-β-driven EMT in cancer progression and drug resistanceSemantic proximity Read ↗

Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition.Semantic proximity Read ↗

EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell linesSemantic proximity Read ↗

EGFR mutations induce the suppression of CD8+ T cell and anti-PD-1 resistance via ERK1/2-p90RSK-TGF-β axis in non-small cell lung cancer.Semantic proximity Read ↗

TGF-β and microRNA Interplay in Genitourinary CancersSemantic proximity Read ↗

Implications of MicroRNAs in the Treatment of Gefitinib-Resistant Non-Small Cell Lung Cancer.Semantic proximity Read ↗

TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer.Semantic proximity Read ↗

The miR‑625‑3p/AXL axis induces non‑T790M acquired resistance to EGFR‑TKI via activation of the TGF‑β/Smad pathway and EMT in EGFR‑mutant non‑small cell lung cancer.Semantic proximity Read ↗

Network Modeling of TGFβ Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway ActivationSemantic proximity Read ↗

Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.