Structural Annotation of Mycobacterium tuberculosis Proteome

Abstract excerpt

Of the ∼4000 ORFs identified through the genome sequence of Mycobacterium tuberculosis (TB) H37Rv, experimentally determined structures are available for 312. Since knowledge of protein structures is essential to obtain a high-resolution understanding of the underlying biology, we seek to obtain a structural annotation for the genome, using computational methods. Structural models were obtained and validated for...

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• Machine Learning in Bioinformatics
• RNA and protein synthesis mechanisms
• Tuberculosis Research and Epidemiology