Article
Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse.
RNA biology - 2 Nov 2017
Filippini Alice, Bonini Daniela, Lacoux Caroline, Pacini Laura, Zingariello Maria, Sancillo Laura, Bosisio Daniela, Salvi Valentina, Mingardi Jessica, La Via Luca, Zalfa Francesca, Bagni Claudia, Barbon Alessandro
Abstract excerpt
The fragile X syndrome (FXS), the most common form of inherited intellectual disability, is due to the absence of FMRP, a protein regulating RNA metabolism. Recently, an unexpected function of FMRP in modulating the activity of Adenosine Deaminase Acting on RNA (ADAR) enzymes has been reported both in Drosophila and Zebrafish. ADARs are RNA-binding proteins that increase transcriptional complexity through a...
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