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Article

TFEB activation restores migration ability to Tsc1-deficient adult neural stem/progenitor cells.

Human molecular genetics - 1 Sept 2017

Magini Alessandro, Polchi Alice, Di Meo Danila, Mariucci Giuseppina, Sagini Krizia, De Marco Federico, Cassano Tommaso, Giovagnoli Stefano, Dolcetta Diego, Emiliani Carla

Abstract excerpt

Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder caused by mutations in either of two genes, TSC1 or TSC2, resulting in the constitutive activation of the mammalian target of rapamycin complex 1 (mTORC1). mTOR inhibitors are now considered the treatment of choice for TSC disease. A major pathological feature of TSC is the development of subependymal giant cell astrocytomas (SEGAs) in the...

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Source

Identifiers

PMID: 28637240
DOI: 10.1093/hmg/ddx214

Genes

TFEB
TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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