Article
Plasminogen Activator Inhibitor Type-1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetes Mellitus Type 2 and Diabetic Retinopathy.
Current eye research - 1 Jul 2017
Siokas Vasileios, Dardiotis Efthimios, Sokolakis Thomas, Kotoula Maria, Tachmitzi Sophia V, Chatzoulis Dimitrios Z, Almpanidou Pavlina, Stefanidis Ioannis, Hadjigeorgiou Georgios M, Tsironi Evangelia E
Abstract excerpt
BACKGROUND: There is accumulating evidence for genetic susceptibility to the development of diabetic retinopathy (DR). The role of plasminogen activator inhibitor-1 (PAI-1) in DR risk remains controversial. OBJECTIVE: The present study was designed to investigate possible influence of PAI-1 gene region polymorphisms on the risk of DR and on the risk of developing DR early vs late in the course of type 2 diabetes...
Topics
- DNA
- Diabetes Mellitus, Type 2
- Diabetic Retinopathy
- Exons
- Female
- Genotype
- Humans
- Male
- Plasminogen Activator Inhibitor 1
- Polymorphism, Single Nucleotide