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Article

Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication

1 Jun 2017

Abstract excerpt

Cholesterol 25-hydroxylase (CH25H) catalyses the production of 25-hydroxycholesterol (25HC) from cholesterol by adding a second hydroxyl group at position 25. The aim of this study was to examine the antiviral effect of CH25H on pseudorabies virus (PRV), a swine pathogen that can cause devastating disease and economic losses worldwide. The results showed that porcine ch25h was induced by either interferon or PRV...

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PMID: 28631596
DOI: 10.1099/jgv.0.000797

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