Article
Association between epidermal growth factor receptor amplification and ADP-ribosylation factor 1 methylation in human glioblastoma.
Cellular oncology (Dordrecht, Netherlands) - 1 Aug 2017
López-Ginés Concha, Navarro Lara, Muñoz-Hidalgo Lisandra, Buso Enrique, Morales José Manuel, Gil-Benso Rosario, Gregori-Romero Mariela, Megías Javier, Roldán Pedro, Segura-Sabater Remedios, Almerich-Silla José Manuel, Monleón Daniel, Cerdá-Nicolás Miguel
Abstract excerpt
PURPOSE: Glioblastoma (GB) is the most frequent and most malignant primary brain tumor in adults. Previously, it has been found that both genetic and epigenetic factors may play critical roles in its etiology and prognosis. In addition, it has been found that the epidermal growth factor receptor gene (EGFR) is frequently over-expressed and amplified in primary GBs. Here, we assessed the promoter methylation...
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