Article
Targeting reactive nitrogen species suppresses hereditary pancreatic cancer.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 2017
Li Mo, Chen Qian, Ma Teng, Yu Xiaochun
Abstract excerpt
Germline mutation of BRCA2 induces hereditary pancreatic cancer. However, how BRCA2 mutation specifically induces pancreatic tumorigenesis remains elusive. Here, we have examined a mouse model of Brca2-deficiency-induced pancreatic tumors and found that excessive reactive nitrogen species (RNS), such as nitrite, are generated in precancerous pancreases, which induce massive DNA damage, including DNA double-strand...
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