Article
The association between detected drug resistance mutations and CD4+ T-cell decline in HIV-positive individuals maintained on a failing treatment regimen.
Antiviral therapy - 1 Jan 2018
Schultze Anna, Paredes Roger, Sabin Caroline, Phillips Andrew N, Pillay Deenan, Mackie Nicola, Castagna Antonella, Chadwick David, Falconer Karolin, Geretti Anna Maria, Post Frank A, Hill Teresa, Kirk Ole, Pozniak Anton, Nelson Mark, Tostevin Anna, Dunn David, Lundgren Jens, Cozzi-Lepri Alessandro
Abstract excerpt
BACKGROUND: To analyse the effect of drug resistance mutations (DRM) on CD4+ T-cell (CD4) trends in HIV-positive people maintained on virologically failing antiretroviral therapy (ART). METHODS: Individuals from two large cohorts experiencing virological failure (VF) while maintained on ART with ≥1 CD4 count and ≥1 resistance test were included. CD4 slopes were estimated using linear mixed models. Principal...
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