Article
Genetic variation in the obesity gene FTO is not associated with decreased fat oxidation: the NEO study.
International journal of obesity (2005) - 1 Oct 2017
Blauw L L, Noordam R, Trompet S, Berbée J F P, Rosendaal F R, van Heemst D, van Dijk K W, Mook-Kanamori D O, de Mutsert R, Rensen P C N
Abstract excerpt
BACKGROUND: The fat mass and obesity-associated (FTO) gene harbors the strongest common genetic variant associated with obesity. Recently, rs1421085-T to -C substitution mapped in FTO was shown to induce a developmental shift of human adipocytes from an energy-combusting beige to an energy-storing white phenotype in vitro. As browning of adipocytes selectively enhances fat oxidation (FatOx), we hypothesized that...
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