Article
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.
Developmental cell - 10 Jul 2017
Kanie Tomoharu, Abbott Keene Louis, Mooney Nancie Ann, Plowey Edward Douglas, Demeter Janos, Jackson Peter Kent
Abstract excerpt
Highly conserved intraflagellar transport (IFT) protein complexes direct both the assembly of primary cilia and the trafficking of signaling molecules. IFT complexes initially accumulate at the base of the cilium and periodically enter the cilium, suggesting an as-yet-unidentified mechanism that triggers ciliary entry of IFT complexes. Using affinity-purification and mass spectrometry of interactors of the...
Topics
- Animals
- Cell Cycle Proteins
- Centrioles
- Cilia
- Ciliopathies
- Flagella
- Gene Knockout Techniques
- Guanosine Triphosphate
- Mice, Inbred C57BL
- Mice, Knockout
- Multiprotein Complexes
- Nucleotides
- Phenotype
- Protein Binding