Article
A formalin-fixed paraffin-embedded (FFPE)-based prognostic signature to predict metastasis in clinically low risk stage I/II microsatellite stable colorectal cancer.
Cancer letters - 10 Sept 2017
Low Yee Syuen, Blöcker Christopher, McPherson John R, Tang See Aik, Cheng Ying Ying, Wong Joyner Y S, Chua Clarinda, Lim Tony K H, Tang Choong Leong, Chew Min Hoe, Tan Patrick, Tan Iain B, Rozen Steven G, Cheah Peh Yean
Abstract excerpt
Approximately 20% early-stage (I/II) colorectal cancer (CRC) patients develop metastases despite curative surgery. We aim to develop a formalin-fixed and paraffin-embedded (FFPE)-based predictor of metastases in early-stage, clinically-defined low risk, microsatellite-stable (MSS) CRC patients. We considered genome-wide mRNA and miRNA expression and mutation status of 20 genes assayed in 150 fresh-frozen tumours...
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