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Article

Medullary Thyroid Carcinoma in MEN2A: ATA Moderate- or High-Risk RET Mutations Do Not Predict Disease Aggressiveness.

The Journal of clinical endocrinology and metabolism - 1 Aug 2017

Voss Rachel K, Feng Lei, Lee Jeffrey E, Perrier Nancy D, Graham Paul H, Hyde Samuel M, Nieves-Munoz Frances, Cabanillas Maria E, Waguespack Steven G, Cote Gilbert J, Gagel Robert F, Grubbs Elizabeth G

Abstract excerpt

Context: High-risk RET mutations (codon 634) are associated with earlier development of medullary thyroid carcinoma (MTC) and presumed increased aggressiveness compared with moderate-risk RET mutations. Objective: To determine whether high-risk RET mutations are more aggressive. Design: Retrospective cohort study using institutional multiple endocrine neoplasia type 2 registry. Setting: Tertiary cancer care...

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Source

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Identifiers

PMID: 28609830
DOI: 10.1210/jc.2017-00317
PMCID: PMC5546858

Genes

RET
DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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