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Article

Angiotensin II type 1 receptor A1166C polymorphism and prophylactic indomethacin treatment induced ductus arteriosus closure in very low birth weight neonates.

Pediatric research - 1 Nov 2003

Treszl Andras, Szabo Miklos, Dunai Gyorgy, Nobilis Andras, Kocsis Istvan, Machay Tamas, Tulassay Tivadar, Vasarhelyi Barna

Abstract excerpt

Altered pulmonary vascular resistance might be a factor for delayed closure of the ductus arteriosus (DA) in preterm infants. Angiotensin II plays a central role in the elevation of pulmonary vascular resistance. Angiotensin II exerts its vasoconstrictor effect on the angiotensin II type 1 receptor (AT1R). Homozygous carriers of the AT1R A1166C genetic variant present an exaggerated vasoconstrictor response to...

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PMID: 12904590
DOI: 10.1203/01.PDR.0000088016.67117.39

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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