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Article

Nonlesional atopic dermatitis skin shares similar T-cell clones with lesional tissues.

Allergy - 1 Dec 2017

Brunner P M, Emerson R O, Tipton C, Garcet S, Khattri S, Coats I, Krueger J G, Guttman-Yassky E

Abstract excerpt

BACKGROUND: Atopic dermatitis (AD) is characterized by robust immune activation. Various T-cell subsets, including Th2/Th22 cells, are increased in lesional and nonlesional skin. However, there is conflicting literature on the diversity of the T-cell receptor (TCR) repertoire in lesional AD, and its relation to nonlesional skin remains unclear. METHODS: We performed high-throughput deep sequencing of the β-TCR...

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Share to Adolescent
Share to Clonal Evolution
Share to Dermatitis, Atopic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Immunoglobulin E

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocyte Subsets

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Source

Identifiers

PMID: 28599078
DOI: 10.1111/all.13223

Genes

CCL17
CXCL10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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