Article
A study of familial MELAS: evaluation of A3243G mutation, clinical phenotype, and magnetic resonance spectroscopy-monitored progression.
Neurology India - 1 Jan 2000
Chen Chunnuan, Xiong Nian, Wang Yuhui, Xiong Jing, Huang Jinsha, Zhang Zhentao, Wang Tao
Abstract excerpt
The clinical manifestations of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes syndrome (MELAS syndrome) are nonspecific and can easily be misdiagnosed. Magnetic resonance spectroscopy (MRS)-based detection of lactate in the brain has been found to be of diagnostic help in MELAS syndrome, however, the issue of whether MRS features vary by stage remains unresolved. We assessed the...
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