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Article

Exome Sequencing Identifies Two Variants of the Alkylglycerol Monooxygenase Gene as a Cause of Relapses in Visceral Leishmaniasis in Children, in Sudan.

The Journal of infectious diseases - 1 Jul 2017

Marquet Sandrine, Bucheton Bruno, Reymond Camille, Argiro Laurent, El-Safi Sayda Hassan, Kheir Musa Mohamed, Desvignes Jean-Pierre, Béroud Christophe, Mergani Adil, Hammad Awad, Dessein Alain J

Abstract excerpt

Background: Visceral leishmaniasis (kala-azar, KA) is the most severe form of leishmaniasis, characterized by fever, weight loss, hepatosplenomegaly, and lymphadenopathy. During an outbreak of KA in Babar El Fugara (Sudan), 5.7% of cured patients displayed relapses, with familial clustering in half the cases. Methods: We performed whole-exome sequencing on 10 relapsing individuals and 11 controls from 5 nuclear...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28586473
DOI: 10.1093/infdis/jix277

Genes

AGMO

Variants

rs139309795
rs143439626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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