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Article

Postnatal Development of Spasticity Following Transgene Insertion in the Mouse βIV Spectrin Gene (SPTBN4).

Journal of neuromuscular diseases - 1 Jan 2000

Kichkin Eva, Visvanathan Archunan, Lovicu Frank J, Shu Daisy Y, Das Shannon J, Reddel Stephen W, McCann Emily P, Zhang Katharine Y, Williams Kelly L, Blair Ian P, Phillips William D

Abstract excerpt

BACKGROUND: The L25 mouse line was generated by random genomic insertion of a lens-specific transgene. Inbreeding of L25 hemizygotes revealed an unanticipated spastic phenotype in the hind limbs. OBJECTIVE: The goals were to characterize the motor phenotype in the L25 mice and to map the transgene insert site within the mouse genome. METHODS: Six pairs of L25+/- mice were repeatedly mated. Beginning at weaning,...

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Source

Identifiers

PMID: 28582869
DOI: 10.3233/JND-160197

Genes

SPTBN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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