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Article

Spectrin mutations that cause spinocerebellar ataxia type 5 impair axonal transport and induce neurodegeneration in Drosophila.

The Journal of cell biology - 5 Apr 2010

Lorenzo Damaris N, Li Min-gang, Mische Sarah E, Armbrust Karen R, Ranum Laura P W, Hays Thomas S

Abstract excerpt

Spinocerebellar ataxia type 5 (SCA5) is an autosomal dominant neurodegenerative disorder caused by mutations in the SPBTN2 gene encoding beta-III-spectrin. To investigate the molecular basis of SCA5, we established a series of transgenic Drosophila models that express human beta-III-spectrin or fly beta-spectrin proteins containing SCA5 mutations. Expression of the SCA5 mutant spectrin in the eye causes a...

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Identifiers

PMID: 20368622
DOI: 10.1083/jcb.200905158
PMCID: PMC2854382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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