Article
Matrix-Bound Nanovesicles Recapitulate Extracellular Matrix Effects on Macrophage Phenotype.
Tissue engineering. Part A - 1 Nov 2017
Huleihel Luai, Bartolacci Joseph G, Dziki Jenna L, Vorobyov Tatiana, Arnold Brooke, Scarritt Michelle E, Pineda Molina Catalina, LoPresti Samuel T, Brown Bryan N, Naranjo Juan Diego, Badylak Stephen F
Abstract excerpt
The early macrophage response to biomaterials has been shown to be a critical and predictive determinant of downstream outcomes. When properly prepared, bioscaffolds composed of mammalian extracellular matrix (ECM) have been shown to promote a transition in macrophage behavior from a proinflammatory to a regulatory/anti-inflammatory phenotype, which in turn has been associated with constructive and functional...
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