Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GTPase Sar1 regulates the trafficking and secretion of the virulence factor gp63 in Leishmania.

The Journal of biological chemistry - 21 Jul 2017

Parashar Smriti, Mukhopadhyay Amitabha

Abstract excerpt

Metalloprotease gp63 (Leishmania donovani gp63 (Ldgp63)) is a critical virulence factor secreted by Leishmania However, how newly synthesized Ldgp63 exits the endoplasmic reticulum (ER) and is secreted by this parasite is unknown. Here, we cloned, expressed, and characterized the GTPase LdSar1 and other COPII components like LdSec23, LdSec24, LdSec13, and LdSec31 from Leishmania to understand their role in ER...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COP-Coated Vesicles
Share to Cytosol
Share to Intracellular Membranes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leishmania donovani

Share to Metalloendopeptidases

Share to Organisms, Genetically Modified

Share to Protein Interaction Domains and Motifs

Share to Vesicular Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28576830
DOI: 10.1074/jbc.M117.784033
PMCID: PMC5519363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GTPase Sar1 regulates the trafficking and secretion of the virulence factor gp63 in Leishmania.PMID 28576830Read ↗

Absence of metalloprotease GP63 alters the protein content of Leishmania exosomes.Semantic proximity Read ↗

Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.Semantic proximity Read ↗

In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasionSemantic proximity Read ↗

The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a functionSemantic proximity Read ↗

p125 Is Localized in Endoplasmic Reticulum Exit Sites and Involved in Their OrganizationSemantic proximity Read ↗

The G1 Cyclin-dependent Kinase CRK1 in Trypanosoma brucei Regulates Anterograde Protein Transport by Phosphorylating the COPII Subunit Sec31.Semantic proximity Read ↗

SAR1 paralogs differ biochemically in assembly of the COPII coatSemantic proximity Read ↗

The protein sequence predicted from a Leishmania guyanensis gp63 major surface glycoprotein gene is divergent as compared with other Leishmania species.Semantic proximity Read ↗

The Sec63p J-domain is required for ERAD of soluble proteins in yeast.Semantic proximity Read ↗

Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway.Semantic proximity Read ↗

Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo via a diacidic motifSemantic proximity Read ↗

Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated Degradation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.