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Article

Expanding the search for significant EGFR mutations in NSCLC outside of the tyrosine kinase domain with next-generation sequencing.

Medical oncology (Northwood, London, England) - 1 Jul 2017

Stein Matthew K, Morris Lindsay, Sullivan Jennifer L, Fenton Moon, VanderWalde Ari, Schwartzberg Lee S, Martin Mike G

Abstract excerpt

While conventional organization of EGFR mutations in non-small cell lung cancer (NSCLC) includes classic lesions sensitive to tyrosine kinase inhibitors (TKI) and variants localized to the tyrosine kinase domain (TKD) in exons 18-21, next-generation sequencing (NGS) raises the prospect of identifying clinically relevant variants in extra-TKD regulatory regions. NSCLC patients at our institution who received tumor...

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PMID: 28573640
DOI: 10.1007/s12032-017-0985-3

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EGFR
ECD

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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