Article
Functional evidence for derivation of systemic histiocytic neoplasms from hematopoietic stem/progenitor cells.
Blood - 13 Jul 2017
Durham Benjamin H, Roos-Weil Damien, Baillou Claude, Cohen-Aubart Fleur, Yoshimi Akihide, Miyara Makoto, Papo Matthias, Hélias-Rodzewicz Zofia, Terrones Nathalie, Ozkaya Neval, Dogan Ahmet, Rampal Raajit, Urbain Fanny, Le Fèvre Lucie, Diamond Eli L, Park Christopher Y, Papo Thomas, Charlotte Frédéric, Gorochov Guy, Taly Valérie, Bernard Olivier A, Amoura Zahir, Abdel-Wahab Omar, Lemoine François M, Haroche Julien, Emile Jean-François
Abstract excerpt
Langerhans cell histiocytosis (LCH) and the non-LCH neoplasm Erdheim-Chester disease (ECD) are heterogeneous neoplastic disorders marked by infiltration of pathologic macrophage-, dendritic cell-, or monocyte-derived cells in tissues driven by recurrent mutations activating MAPK signaling. Although recent data indicate that at least a proportion of LCH and ECD patients have detectable activating kinase mutations...
Topics
- Adult
- Alleles
- Animals
- Antigens, CD34
- Bone Marrow Cells
- Bone Marrow Transplantation
- Cell Differentiation
- DNA-Binding Proteins