Tensile strength suppresses the osteogenesis of periodontal ligament cells in inflammatory microenvironments.

doi:10.3892/mmr.2017.6644

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Article

Tensile strength suppresses the osteogenesis of periodontal ligament cells in inflammatory microenvironments.

Molecular medicine reports - 1 Jul 2017

Sun Chaofan, Liu Fen, Cen Shendan, Chen Lijiao, Wang Yi, Sun Hao, Deng Hui, Hu Rongdang

Abstract excerpt

The present study aimed to investigate the role of orthodontic force in osteogenesis differentiation, matrix deposition and mineralization in periodontal ligament cells (PDLCs) cells in inflammatory microenvironments. The mesenchymal origin of PDLCs was confirmed by vimentin and cytokeratin staining. PDLCs were exposed to inflammatory cytokines (5 ng/ml IL‑1β and 10 ng/ml TNF‑α) and/or tensile strength (0.5 Hz,...

Topics

Adolescent
Adult
Alkaline Phosphatase
Calcification, Physiologic
Cells, Cultured
Cellular Microenvironment
Cytokines
Extracellular Matrix
Female
Humans
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inflammation Mediators

Male

Osteogenesis

Periodontal Ligament

Periodontitis

Phenotype

Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 28560407
DOI: 10.3892/mmr.2017.6644
PMCID: PMC5482070

Genes

RUNX2
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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