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Article

Low dystrophin levels in heart can delay heart failure in mdx mice

30 Jan 2014

Abstract excerpt

Duchenne muscular dystrophy is caused by mutations that prevent synthesis of functional dystrophin. All patients develop dilated cardiomyopathy. Promising therapeutic approaches are underway that successfully restore dystrophin expression in skeletal muscle. However, their efficiency in the heart is limited. Improved quality and function of only skeletal muscle potentially accelerate the development of...

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Identifiers

PMID: 24486194
DOI: 10.1016/j.yjmcc.2014.01.009

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