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Article

Family environments and leukocyte transcriptome indicators of a proinflammatory phenotype in children and parents.

Development and psychopathology - 1 Feb 2018

Robles Theodore F, Repetti Rena L, Reynolds Bridget M, Chung Paul J, Arevalo Jesusa M G, Cole Steven W

Abstract excerpt

High conflict and low warmth in families may contribute to immune cells developing a tendency to respond to threats with exaggerated inflammation that is insensitive to inhibitory signaling. We tested associations between family environments and expression of genes bearing response elements for transcription factors that regulate inflammation: nuclear factor kappa B (NF-κB) and glucocorticoid receptor. The...

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PMID: 28555535
DOI: 10.1017/S0954579417000591

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