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Article

A tripeptidyl peptidase 1 is a binding partner of the Golgi pH regulator (GPHR) in Dictyostelium.

Disease models & mechanisms - 1 Jul 2017

Stumpf Maria, Müller Rolf, Gaßen Berthold, Wehrstedt Regina, Fey Petra, Karow Malte A, Eichinger Ludwig, Glöckner Gernot, Noegel Angelika A

Abstract excerpt

Mutations in tripeptidyl peptidase 1 (TPP1) have been associated with late infantile neuronal ceroid lipofuscinosis (NCL), a neurodegenerative disorder. TPP1 is a lysosomal serine protease, which removes tripeptides from the N-terminus of proteins and is composed of an N-terminal prodomain and a catalytic domain. It is conserved in mammals, amphibians, fish and the amoeba Dictyostelium discoideum. D. discoideum...

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Source

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Identifiers

PMID: 28546289
DOI: 10.1242/dmm.029280
PMCID: PMC5536908

Genes

TPP1
NCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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