Article
Regulation of acetyl-CoA synthetase transcription by the CrbS/R two-component system is conserved in genetically diverse environmental pathogens.
PloS one - 1 Jan 2017
Jacob Kristin, Rasmussen Anna, Tyler Paul, Servos Mariah M, Sylla Mariame, Prado Cecilia, Daniele Elizabeth, Sharp Josh S, Purdy Alexandra E
Abstract excerpt
The CrbS/R two-component signal transduction system is a conserved regulatory mechanism through which specific Gram-negative bacteria control acetate flux into primary metabolic pathways. CrbS/R governs expression of acetyl-CoA synthase (acsA), an enzyme that converts acetate to acetyl-CoA, a metabolite at the nexus of the cell's most important energy-harvesting and biosynthetic reactions. During infection,...
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