Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Aberrant Expression of Rb and pRb-780, pRb-795 in Lung Adenocarcinoma Patients with EGFR Mutations and Their Clinical Significance].

Zhongguo fei ai za zhi = Chinese journal of lung cancer - 20 May 2017

Dong Yunlong, Liu Minghui, Li Yongwen, Li Ying, Zhao Chenlong, Yuan Yin, Du Hui, Zhang Zihe, Zhang Hongbing, Liu Hongyu, Chen Jun

Abstract excerpt

BACKGROUND: Rb is an important tumor suppressor gene that regulates cell cycle progression. Rb dysfunction can lead to over proliferation of cells and lead to the occurrence of tumor. Loss or reduced Rb expression as well as over phosphorylation of Rb are important mechanisms of Rb dysfunction. The mutated epidermal growth factor receptor (EGFR) gene is an important driver gene in lung adenocarcinoma, and plays...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to Gene Expression Regulation, Neoplastic

Share to Lung Neoplasms

Share to Phosphorylation

Share to Retinoblastoma Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 28532538
DOI: 10.3779/j.issn.1009-3419.2017.05.03
PMCID: PMC5973063

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Aberrant Expression of Rb and pRb-780, pRb-795 in Lung Adenocarcinoma Patients with EGFR Mutations and Their Clinical Significance].PMID 28532538Read ↗

Clinical significance of the Rb expression in adenocarcinoma of the lung.Semantic proximity Read ↗

Association between EGFR mutation and expression of BRCA1 and RAP80 innon-small cell lung cancerSemantic proximity Read ↗

Regulation of the G1/S phase of the cell cycle and alterations in the RB pathway in human lung cancerSemantic proximity Read ↗

Increased phosphorylation of ERK1/2 is associated with worse chemotherapeutic outcome and a poor prognosis in advanced lung adenocarcinoma.Semantic proximity Read ↗

RB and cyclin dependent kinase pathways: defining a distinction between RB and p16 loss in lung cancerSemantic proximity Read ↗

[Relationship between histopathologic characteristics and epidermal growth factor receptor mutation in lung adenocarcinoma].Semantic proximity Read ↗

TRB3 interacts with ERK and JNK and contributes to the proliferation, apoptosis, and migration of lung adenocarcinoma cellsSemantic proximity Read ↗

ERβ1 Expression Patterns Have Different Effects On EGFR TKIs Treatment Response in EGFR Mutant Lung Adenocarcinomas.Semantic proximity Read ↗

Retinoblastoma Regulatory Pathway in Lung CancerSemantic proximity Read ↗

[Relationship between expression of anaplastic lymphoma kinase in pleural effusion and clinicopathological features of patients with lung adenocarcinoma and the response to crizotinib].Semantic proximity Read ↗

[Expression of epidermal growth factor receptor mutation specific antibodies in lung adenocarcinoma: evaluation of sensitivity, specificity and relationship to histologic subtypes].Semantic proximity Read ↗

Altered expression of the cell cycle regulatory molecules pRb, p53 and MDM2 exert a synergetic effect on tumor growth and chromosomal instability in non-small cell lung carcinomas (NSCLCs).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.